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Ejection fraction (EF) is a measurement cardiologists use to assess the strength of the heart. It represents a comparison of how much blood is retained by one ventricle of the heart at the beginning of a beat with how much blood remains after the ventricle completes the beat.
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Van Rooj et. al. demonstrated that the inhibition of miR-208a by systemic delivery of locked nucleic acid–modified antisense oligonucleotide prevented cardiac remodeling in a rat model of LV failure. This technology also prevented pathological myosin switching and cardiac remodeling, while improving cardiac function .
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